The gas-sensing capsule, when swallowed, can electronically report important data about the human gastrointestinal system by detecting gases in real-time from known locations within the gut and using these biomarkers for diagnosis, resulting in targeted treatment, earlier relief of symptoms and reduced healthcare costs.
The ingestible capsule offers a potential diagnostic tool for many disorders of the gut from motility disorders, IBS and IBD to liver disease.
The Atmo Gas Capsule is currently an investigational device exclusively for use in clinical investigations, and is not available for sale.
Gut disorders are one of the most common ailments in the world affecting tens of millions of people.
These disorders include motility abnormalities, SIBO, IBS and IBD. Gases are important biomarkers of disease, dysfunction and dysbiosis.
20% of people suffer from gastrointestinal disorders in their lifetime.
30% of patients remain undiagnosed and suffer from the recurrence of disorders.
IBS affects 25 to 45 million people in the USA and 2 to 5 million in Australia.
GI disorders and disease treatment market (2013 USD).
Unfortunately, current diagnostic methods for gastrointestinal disorders are often highly invasive or rely on subjective symptomatology and questionnaires.
Diagnostic methods such as aspiration, biopsy, endoscopy, motility pills, imaging pills and breath testing all have limitations.
Gas sensing in real-time from within the gut is an accurate, convenient method of diagnosing the common GI conditions affecting the millions of sufferers of food intolerances, motility disorders, SIBO and IBS.
- Jack Gilbert, Microbiologist and Director of the Microbiome Center at the University of Chicago. Source: NPR
A safe and accurate way of measuring the concentration of various gases at the source of production in the gastrointestinal tract (GI tract) in real-time.
The Atmo Gas Capsule allows tests to be performed at home, without impacting daily activities.
Patient attends physician’s office to discuss their condition.
Patient swallows Gas Capsule with a standard meal.
Data is continuously transmitted from the Gas Capsule to the receiver. At capsule exit, data are sent to the Cloud for aggregation, analysis and patient reporting.
Patient goes about their daily activities.
Capsule exit is detected when Gas Capsule has been expelled. No retrieval is necessary.
Data is analysed and the physician discusses the results with the patient.
Within the Atmo Gas Capsule's 2cm-long polymer shell are gas sensors, a temperature sensor, a microcontroller, a radio-frequency transmitter, and button-sized silver-oxide batteries. The gas sensors are sealed within a special membrane that allows gas in but keeps out stomach acid and digestive juices.
The technology works by using sensors to measure different gases by adjusting their heating elements, and the data can then be transmitted to a mobile phone. Oxygen concentrations are used to track the capsule's progress throughout the GI tract.
Data is transmitted in real-time to a small receiver that can be carried in a pocket or left on the nightstand when someone is home. The receiver in turn transmits the data via Bluetooth to a cell phone, which can post the data online for easy monitoring by users and doctors.
Clinical trials of the Atmo Gas Capsule were conducted on 23 healthy participants adhering to either a low- or high-fibre diet. Results showed that the capsule is safe and reliable, and accurately shows the onset of food fermentation, highlighting their potential to clinically monitor digestion and normal gut health. The trials also demonstrated that the Atmo Gas Capsule could offer a much more effective way of measuring microbiome activities in the stomach, a critical way of determining gut health.
READ PUBLISHED ARTICLEThe current method for measuring gas biomarkers is using breath tests. Breath tests, however, are an indirect measurement technique requiring the gases that are generated in the gut to be absorbed into the blood stream, circulated around the body, transferred into the lungs and finally exhaled out of the mouth. For this reason breath tests show low specificity and sensitivity when compared to the direct method used by the Atmo Gas Capsule.
The Atmo Biosciences Gas Capsule has a unique set of benefits that could revolutionise the way gut disorders and diseases are diagnosed and managed.
At the source of gas production within the gut
Up to 10,000 times better than current standards
Patient data can be aggregated for clinical analysis and predictive algorithms
Cheaper than all current methods
Patients go about their normal life
The size of a common vitamin pill
Data transmitted wirelessly to receiver, phone app and cloud in real-time from known location in the gut
Potential applications span malabsorption to IBD
17 May, 2023. Preliminary results from a University of Queensland (UQ) study to assess how the Atmo Gas Capsule compares to established SIBO (small intestinal bacterial overgrowth) diagnostic methods suggest a good correlation with duodenal aspirate and higher accuracy than a breath test. Dr Ayesha Shah, a senior lecturer at the UQ School of Medicine, presented data from the study, led by Professor Gerald Holtmann, also from UQ, and Professor Uda...
15 May, 2023. A Western Sydney University (WSU) and Monash University comparative study has validated the Atmo Gas Capsule relative to the SmartPill when measuring gastric emptying time and colonic transit time in patients with gastroparesis and chronic constipation. Dr Jerry Zhou, lecturer and clinical researcher at WSU School of Medicine, presented findings from the study in a poster presentation at Digestive Disease Week (DDW), held May 6-9...
1 May, 2023. Atmo Biosciences today announced the appointment of renowned gastroenterologist Professor Eamonn Quigley as Chair of its Medical Advisory Board (MAB). Prof. Quigley is David M. Underwood Chair of Medicine in Digestive Disorders and Chief of Gastroenterology and Hepatology at Houston Methodist Hospital in Texas. He is internationally known for his research on gastrointestinal motility disorders, particularly irritable bowel syndrom...
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CEO and Co-Founder
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VP Technology and Co-Founder
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Head of Commercial
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Houston Methodist Hospital, Weill Cornell Medical College
Monash University, The Alfred
University of Michigan
Augusta University
Massachusetts General Hospital, Harvard Medical School
Cleveland Clinic
University of California
