Gas capsule trial at RMIT
Results show Atmo Gas Capsule can be used to assess whole gut transit times

A multicenter study, including 43 patients with suspected dysmotility ingested the Atmo capsule and SmartPill simultaneously and researchers compared the transit times of the two capsules through the different regions of the gastrointestinal tract.

SmartPill uses pH, temperature and pressure to identify when the pill moves through different gut regions, whereas the Atmo capsule uses a range of measures including hydrogen and carbon dioxide concentration, and temperature.

Results showed the two devices had similar transit times and diagnostic agreement, thereby validating the Atmo capsule relative to SmartPill for measurements of gastric emptying time and colonic transit time for patients with gastroparesis and chronic constipation.

The study follows a clinical trial demonstrating strong agreement between the Atmo Gas Capsule and SmartPill for measuring transit time in healthy subjects.The results showed that the Atmo Gas Capsule was readily ingested, well-tolerated and technically reliable.

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Gas concentrations in the gut are 5,000 to 10,000 times higher than those in the breath, which results in the Capsule’s superior signal to noise ratio when compared to breath testing.

The current method for measuring gas biomarkers is using breath tests. Breath tests, however, are an indirect measurement technique requiring the gases that are generated in the gut to be absorbed into the blood stream, circulated around the body, transferred into the lungs and finally exhaled out of the mouth. For this reason breath tests show low specificity and sensitivity when compared to the direct method used by the Atmo Gas Capsule.

Breath Test Comparison Chart TXH 04-01